Journal article
Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis
D Cromer, M Steain, A Reynaldi, TE Schlub, SR Khan, SC Sasson, SJ Kent, DS Khoury, MP Davenport
Nature Communications | NATURE PORTFOLIO | Published : 2023
Abstract
Vaccine protection from symptomatic SARS-CoV-2 infection has been shown to be strongly correlated with neutralising antibody titres; however, this has not yet been demonstrated for severe COVID-19. To explore whether this relationship also holds for severe COVID-19, we performed a systematic search for studies reporting on protection against different SARS-CoV-2 clinical endpoints and extracted data from 15 studies. Since matched neutralising antibody titres were not available, we used the vaccine regimen, time since vaccination and variant of concern to predict corresponding neutralising antibody titres. We then compared the observed vaccine effectiveness reported in these studies to the pr..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work would not be possible without the many scientists who generously provided the published data analysed in this study by making the data directly available through the original publication. The authors thank these scientists for their contribution, and the individual sources of data are indicated in the references and supplementary tables. This work was supported by Australian NHMRC program grant 1149990 to S.J.K. and M.P.D., an Australian MRFF award 2005544 to S.J.K. and M.P.D., and MRFF 2015313 to S.C.S. and M.P.D. S.J.K., D.C. and M.P.D. are supported by NHMRC Investigator grants. D.S.K. is supported by a University of New South Wales fellowship.